4 edition of Insulin-like growth factors found in the catalog.
Includes bibliographical references and index.
|Statement||editor, Derek LeRoith.|
|Contributions||LeRoith, Derek, 1945-|
|LC Classifications||QP552.S65 I57 1991|
|The Physical Object|
|Pagination||315 p. :|
|Number of Pages||315|
|LC Control Number||90015160|
Derek LeRoith is the author of Insulin-like Growth Factors and Cancer ( avg rating, 0 ratings, 0 reviews), Diabetes Mellitus ( avg rating, 0 rating 3/5(1). Preface.- Epidemiology of IGF-1 and Cancer.- Aging and Cancer: The IGF-I Connection.- Obesity, Type 2 Diabetes and Cancer.- IGF System and Breast Cancer.- The Role of Insulin-Like Growth Factor Signaling in Prostate Cancer Development and Progression.- Mouse Models of IGF-1 Deficiency.- Insulin-like Growth Factor Signaling in Pediatric Sarcomas.-Author: Derek Leroith.
Physiology. Insulin-like growth factors are single chain polypeptides. There are two principle IGFs referred to as IGF-I and IGF-II. IGF-1 is a polypeptide hormone with a molecular weight of kDa structurally similar to : Emrah Yerlikaya, Fulya Akin. This issue of Endocrinology Clinics, authored by experts worldwide, provides essential updates about insulin-like growth factors (IGFs). The physiology is examined, including the latest in what we have learned from animal models as well as humans.&nPages:
Abstract. Insulin-like growth factor (IGF)-1 and IGF-2, may be important regulatory molecules in the CNS. Possible origins of IGFs in brain include either de novo synthesis or transport of circulating IGFs from blood into brain via receptor mediated transcytosis mechanisms at the brain capillary endothelial wall, ie, the blood-brain barrier (BBB). Throughout evolution the insulin-like growth factors (IGFs), their IGF-binding proteins (IGFBPs) and receptors have had central roles in growth, metabolism and reproduction .There is evidence that the IGF system has an important pathophysiological role across the spectrum of obesity, insulin resistance and type 2 diabetes mellitus, and therefore represents a potential therapeutic by:
Animals on the edge
Americas History 5e & Documents to Accompany Americas History 5e V1 & V2
Lay visitors to police stations in Northern Ireland.
Human biology: elementary anatomy and physiology for students and nurses.
The 2007-2012 World Outlook for Non-Carbonated Fruit Drinks, Cocktails, and Ades Concentrates Containing No Real Juice
On general purpose finite element computer programs
Masters theses in science, 1952.
An Enquiry into the Origin of Honour, and the Usefulness of Christianity in War
A Register of the Scholars Admitted into Merchant Taylors School, from A.D. 1562 to 1699
Rangers Impartial List of the Ladies of Pleasure in Edinburgh
Dr. Wisemans popish literary blunders exposed
Insulin-like growth factor (IGF), formerly called somatomedin, any of several peptide hormones that function primarily to stimulate growth but that also possess some ability to decrease blood glucose levels.
IGFs were discovered when investigators began studying the effects of biological substances on cells and tissues outside Insulin-like growth factors book body. The name insulin-like growth factor reflects the fact. The insulin-like growth factor system has been shown to play a critical role in cancer development and progression.
Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, specifically brings these aspects to the volume covers the epidemiological aspects of the relationships between circulating insulin and IGF-1 levels and the risk for cancer and cancer-related.
Insulin-like growth factor –binding protein-1, Insulin-like growth factors book known as pregnancy-associated α 1-protein and placental prot is a major secretory product of decidual cells. It is one of several proteins that bind IGF-1 and IGF-2, affecting the ability of these growth factors to interact with the IGF receptors.
Consequently, the binding. Insulin-like growth factor (IGF) is a polypeptide hormone similar to insulin. There are two types of insulin-like growth factors, IGF-1 and IGF-2, which are released upon stimulation by the growth hormone.
Insulin-like growth factor binds to the IGF-1 or the IGF-2 receptor and the insulin receptor, and promotes growth and development. Insulin-like Growth Factors 1 and 2 IGF1 synergizes with FSH in the induction of P arom activity in primate granulosa cells as well as with LH in the production of androgens by theca cells.
– As such, IGF1 could contribute to the regulation of estradiol biosynthesis and follicular development. The Insulin-Like Growth Factor I Receptor: Molecular Biology, Heterogeneity and Regulation.
Biological Actions of the Insulin-Like Growth Factors. Insulin-Like Growth Factor II: Gene Structure and Expression into Messenger RNA and Protein. The Insulin-Like Growth Factor-II/Mannose 6-Phosphate Receptor.
Insulin-Like Growth Factor Binding Proteins. Until recently, insulin-like growth factors (or, as they were originally known, somatomedins) were thought to be produced in the liver in response to growth hormone, to circulate in the blood, and to mediate the effects of growth hormone (GH) on skeletal cartilage to promote bone elongation during childhood (Salmon and Daughaday ).Recent insights have necessitated revision of the Cited by: Insulin-like growth factor is similar to insulin (a hormone made in the pancreas).
There are two forms of insulin-like growth factor called IGF-1 and IGF Higher than normal levels of IGF-1 may increase the risk of several types of cancer. Insulin-like growth factor is a type of growth factor and a type of cytokine.
Order Insulin-like Growth Factors ISBN @ € Qty: Over the past five years there has been an explosion of “targeted therapies” for cancer treatment. In most cases, these therapies have been based on pre-clinical data showing that specific molecules play an.
Read "Insulin-like Growth Factors and Cancer From Basic Biology to Therapeutics" by available from Rakuten Kobo. The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on I Brand: Springer US.
An exciting development in this area is the possibility that insulin and insulin-like growth factors (IGF) are not only produced by neural tissues but also exert profound physiological and biochemical effects on these tissues. The area of investigation of CNS insulin and IGF has been expanding rapidly and the availability of this book complete Cited by: Insulin-like Growth Factors: Molecular and Cellular Aspects - CRC Press Book During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors.
The answer appears to lie in growth factors and their regulation. To thrive and survive we need growth factors and this book concentrates on two factors that are related to growth hormone. Growth hormone does not act directly on all tissues, but mediates many of its actions through the release of insulin-like growth factors from the by: Insulin-Like Growth Factors in Health and Disease, An Issue of Endocrinology and Metabolism Clinics - E-Book.
by Claire M. Perks, MD,Jeff M.P. Holly, MD. The Clinics: Internal Medicine (Book Volume ) Thanks for Sharing. You submitted the following rating and review.
We'll publish them on our site once we've reviewed : Elsevier Health Sciences. Despite improvements in breast cancer therapy in recent years, additional therapies need to be developed. New therapies may have activity by themselves or may have utility in combination with other agents.
Population, preclinical, and basic data suggest the insulin-like growth factor (IGF) system functions to maintain the malignant phenotype in breast by: The C.
elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism, growth, development, longevity, and behavior. This fundamental pathway is regulated by insulin-like peptide ligands that bind to the insulin/IGF-1 transmembrane receptor (IGFR) ortholog DAF DAF-2/IGFR controls the activity of a conserved phosphoinositide 3-kinase (PI3K)/Akt kinase cascade Cited by: Insulin-Like Growth Factor II (IGF-II) and Non-Islet Cell Tumor Hypoglycemia (NICTH) / Naomi Hizuka, Izumi Fukuda, Yukiko Ishikawa and Kazue Takano Diabetes / Tero Saukkonen and David B.
Dunger Insulin-Like Growth Factors in Critical Illness / Greet Van den Berghe Laron Syndrome: Primary GH Insensitivity or Resistance / Zvi Laron. The answer appears to lie in growth factors and their regulation. To thrive and survive we need growth factors and this book concentrates on two factors that are related to growth hormone.
Growth hormone does not act directly on all tissues, but mediates many of its actions through the release of insulin-like growth factors from the : Springer US. Neurotrophic Effects and Mechanism of Insulin, Insulin-Like Growth Factors, and Nerve Growth Factor in Spinal Cord and Peripheral Neurons Pages Ishii, Douglas N.
(et al.). Get this from a library. Insulin-like growth factors in health and disease. [Claire M Perks; Jeff M P Holly;] -- This issue of Endocrinology Clinics, authored by experts worldwide, provides essential updates about insulin-like growth factors (IGFs).
The physiology is examined, including the latest in what we. This issue of Endocrinology Clinics, authored by experts worldwide, provides essential updates about insulin-like growth factors (IGFs). The physiology is examined, including the latest in what we have learned from animal models as well as humans.&n.In the chronic situation, the anabolic and survival factors, insulin-like growth factor-1 (IGF-1) and IGF-2, were upregulated in atrophic and regenerating myocytes together with attenuated HIF Author: Armin Ariana.Insulin-like growth factors: A role in growth hormone negative feedback and body weight regulation via brain Article (PDF Available) in Science April with 25 Reads How we measure.